Most Bet Week 1 NFL Game Is a Primetime Matchup of Buffalo Bills Versus Los Angeles Rams

On your mark, bettors get set, go!

The football season is inching closer to NFL kickoff, and you can almost smell the brats and dogs cooking on the grill. Bettors are already putting their money where there mouths are, and the wagers have been flying in. Most of the NFL offseason betting is about Futures, or Win/Loss Over Unders, but now that the games are about to begin, it’s time to start placing wagers on actual games being played. The marquee matchup of the Buffalo Bills versus the Los Angeles Rams on NFL opening night is fittingly the most bet on game in Week 1 of the NFL slate.


You can see the stats coming in at BetMGM:

So it appears bettors are hammering the Buffalo Bills to cover the spread against the defending Super Bowl Champions. Kickoff from SoFi Stadium is set for 8:20 p.m. ET. Buffalo is a 2.5-point favorite, while the over/under for total points scored is 52.

The Bills have the best Super Bowl odds in the NFL entering Week 1, coming in at +550. That’s slightly ahead of the Tampa Bay Buccaneers (+700) and considerably better than the team with the third-best odds, the Green Bay Packers (+1000). Clearly bettors are feeling the Buffalo Bills this season.

So who wins Bills vs. Rams in the NFL Kickoff Game 2022? And which side of the spread has all the value? You can check out all the best odds at

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